Current position:
Staff Specialist, M.D. (afdelingslæge)
Associate Professor, Ph.D. (klinisk lektor)
Head of Research (forskningansvarlig)
Department of Radiology, Aalborg Hospital, AarhusUniversityHospital
&
Mech-SenseResearchCenter, Aalborg Hosptial, AarhusUniversityHospital
www.mech-sense.com
Personal data:
Jens Brøndum Frøkjær, born June 8th1973 in Frederikshavn, Denmark. Danish citizenship.
Education and academic titles:
2000 M.D., AarhusUniversity, DK
2002 Permission to practice independently as a physician.
National Board of Health, DK.
2006 Ph.D., April 24th 2006, Dept. of Health Science and Technology, AalborgUniversity, DK.
2009 Specialist Approval in Diagnostic Radiology, National Board
of Health, DK.
Scientific positions
2003-2005 Research Assistant, Center for Visceral Biomechanics and
Pain, AalborgHospital, DK.
2006- Affiliated researcher, post doc, Mech-Sense (former Center for Visceral Biomechanics and Pain), AalborgHospital, DK.
2009- Research Coordinator, Department of Radiology, AalborgHospital, DK.
2010- Head of Research, Department of Radiology,
AalborgHospital, DK.
2011- Associate Professor (klinisk lektor), Institute of Clinical Medicine, AarhusUniversity, DK.
Clinical and administrative positions
2000 Medical Doctor, Danish Armed Forces Health Services, Jægersborg, DK
2000 2nd Lieutenant, Leader of Medical Platoon, The Engineering
Regiment, Skive, DK
2001-2010 1st Lieutenant (Reserve Officer), Danish Armed Forces
Health Services, Jægersborg, DK
2001-2002 Resident (rotation: surgery, internal medicine and GP),
Hospital Nord, Nykøbing-Thisted, DK.
2002-2003 Resident (introduction position), Department of
Radiology, AalborgHospital, DK
2005-2007 Resident (reservelæge), Department of Radiology,
AalborgHospital, DK
2007-2008 Resident (reservelæge), Department of Radiology,
ViborgHospital, DK
2008-2009 Specialist Registrar (1.reservelæge), Department of
Radiology, AalborgHospital, DK
2009- Staff Specialist (afdelingslæge), Department of Radiology,
AalborgHospital, DK
Bibliography
Papers published: 37 (4 reviews, first author on 16 papers). Book chapter: 1.
Citation Report: cited 295 times, h-index: 12.
Ph.D. Thesis: Frøkjær JB. Assessment of the Mechanosensory Properties in the Human Gastrointestinal Tract: Neurophysiological, Mechanical and Imaging Studies in Healthy Subjects and in Diabetic Patients [Ph.D. thesis]. Center for Sensory-Motor Interaction (SMI), AalborgUniversity; 2006. ISBN87-90562-48-8.
First author on 35 abstracts (9 oral presentations and 29 first author poster presentations).
Awards
2003- 4 research awards and 3 awarded posters.
Current research interests
Clinical and experimental gastroenterological imaging studies; Neurophysiological brain imaging (EEG, MRI and fMRI); The gut-brain axis; Gastrointestinal pain in health and disease; Diabetic gastroenterology; Development of methods to assess the physiological and nociceptive function of the gut; Visceral motor and sensory function; Soft tissue biomechanics and remodelling; Image processing and 3-D gastrointestinal model reconstruction.
Original peer-reviewed scientific papers
2004
1 McMahon BP, Frøkjær JB, Drewes AM, Gregersen H. A new measurement of oesophago-gastric junction competence. Neurogastroenterol Motil. 2004 Oct;16(5):543-546.
2005
2 Frøkjær JB, Larsen E, Steffensen E, Nielsen AH, Drewes AM. Magnetic resonance imaging of the small bowel in Crohn's disease. Scand.J Gastroenterol. 2005 Jul;40(7):832-842.
3 Frøkjær JB, Liao D, Bergmann A, McMahon BP, Steffensen E, Drewes AM, and Gregersen H. Three-dimensional biomechanical properties of the human rectum evaluated with magnetic resonance imaging. Neurogastroenterol Motil. 2005 Aug;17(4):531-40.
4 McMahon BP, Frøkjær JB, Liao D, Kunwald P, Drewes AM, Gregersen H. A new technique for evaluating sphincter function in visceral organs: application of the functional lumen imaging probe (FLIP) for evaluation of the oesophago-gastric junction. Physiol Meas. 2005 Oct;26(5):823-36.
5 Frøkjær JB, Andersen SD, Gale J, Arendt-Nielsen L, Gregersen H, Drewes AM. An experimental study of viscero-visceral hyperalgesia using an ultrasound-based multimodal sensory testing approach. Pain. 2005 Dec 15; 119(1-3):191-200.
6 Liao D, Frøkjær JB, Drewes AM, Gilja OH, Hausken T, Gregersen H. Three dimensional model analysis in the gastrointestinal tract. In: Rodrigues H, et.al., editors. II International Conference on Computational Bioengineering. Lisbon: IST Press, Portugal; 2005. pp.13-23.
2006
7 Frøkjær JB, Andersen SD, Lundbye-Christensen S, Funch-Jensen F, Drewes AM, Gregersen H. Sensation and Distribution of Stress and Deformation in the Human Esophagus. Neurogastroenterol Motil. 2006 Feb;18(2):104-114.
8 Drewes AM, Frøkjær JB, Larsen E, Reddy H, Arendt-Nielsen L, Gregersen H. Pain and Mechanical Properties of the Rectum in Patients with Active Ulcerative Colitis. Inflamm Bowel Dis. 2006 Apr;12(4):294-303.
9 Liao DH, Frøkjær JB, Yang J, Zhao JB, Drewes AM, Gilja OH, Gregersen H. Three-dimensional surface model analysis in the gastrointestinal tract. World J Gastroenterol 2006 May 14;12(18):2870-5.
10 Zhao JB, Frøkjær JB, Drewes AM & Ejskjaer N. Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus. World J Gastroenterol 2006 May 14;12(18):2846-57.
11 Frøkjær JB, AndersenSD, Drewes AM, Gregersen H. Ultrasound Determined Geometric and Biomechanical Properties of the Human Duodenum. Dig.Dis.Sci. 2006 Sep;51(9):1662-9.
2007
12 McMahon BP, Frøkjær JB, Kunwald P, Liao D, Funch-Jensen P, Drewes AM, Gregersen H. The Functional Lumen Imaging Probe (FLIP) for Evaluation of the Esophagogastric Junction. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1) :G377-84.
13 Frøkjær JB, Liao D, Steffensen E, Dimcevski G, Bergmann A, Drewes AM, Gregersen H. Geometrical and Mechanosensory Properties of the Sigmoid Colon evaluated with Magnetic Resonance Imaging. Neurogastroenterol Motil. 2007 Apr;19(4):253-62.
14 Stender MT, Nielsen TS, Frøkjær JB, Larsen TB, Lundbye-Christensen S, Thorlacius-Ussing O. High preoperative prevalence of deep venous thrombosis in patients with colorectal cancer. Brit J Surg. 2007 Sep;94(9):1100-3.
15 Frøkjær JB, Andersen SD, Ejskjær N, Funch-Jensen P, Arendt-Nielsen L, Gregersen H, Drewes AM. Gut Sensations in Diabetic Autonomic Neuropathy. Pain. 2007 Oct;131(3):320-9. Comment in: Pain. 2007 Oct;131(3):239-40.
16 Frøkjær JB, Andersen SD, Ejskjær N, Funch-Jensen P, Drewes AM, Gregersen H. Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1. World J Gastroenterol. 2007 Sep 28; 13(36):4881-90.
17 Arendt-Nielsen L, Frøkjær JB, Staahl C, Graven-Nielsen T, Huggins JP, Smart TS, Drewes AM, Effect of Gabapentin on Experimental Somatic Pain and Temporal Summation. Reg Anesth Pain Med. 2007 Sep;32(5):382-388.
2008
18 Stender M, Frøkjær JB, Hagedorn Nielsen TS, Larsen TB, Lundbye-Christensen S, Elbrønd H, Thorlacius-Ussing O. Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients. Thromb Haemost. 2008 Feb;99(2):396-400.
19 Liao D, Frøkjær JB, Brock C, Andersen SD, Drewes AM, Gregersen H. Oesophageal Heat Transfer Properties. Oesophageal Heat Transfer Properties Indication of Segmental Blood Flow Changes during Distension. Neurogastroenterol Motil. 2008 Apr;20(4):297-303.
20 Brock C, Nissen TD, Gravesen FH, Frøkjær JB, Omar H, Gale J, Gregersen H, Svendsen O, Drewes AM. Multimodal Sensory Testing of the Rectum and Simoid Colon: Development and Reproducibility of a New Method. Neurogastroenterol Motil. 2008 Aug;20(8):908-18.
21 Frøkjær JB, Ejskjær N, Andersen SD, Rask P, Funch-Jensen P, Arendt-Nielsen L, Gregersen H, Drewes AM. Central Neuronal Mechanisms of Gastric Electrical Stimulation in Diabetic Gastroparesis. Scan.J Gastroenterol. 2008;43(9):1066-75.
2009
22 Frøkjær JB, Drewes AM, Gregersen H. Imaging of the Gastrointestinal Tract – novel Technologies. World J Gastroenterol. 2009 Jan;15(3):160-8.
23 Moesgaard J, Kristensen JH, Malczynski J, Holst-Hansen C, Rees SE, Murley D, Andreassen S, Frøkjær JB, Toft E. Can new pulmonary gas exchange parameters contribute to evaluation of pulmonary congestion in left-sided heart failure? Can J Cardiol. 2009 Mar;25(3):149-55.
24 Stender MT, Frøkjær JB, Larsen TB, Lundbye-Christensen S, Thorlacius-Ussing O. Plasma D-dimer is a predictor of postoperative deep venous thrombosis in colorectal cancer patients: a clinical prospective cohort study with one year follow-up. Dis Colon Rectum 2009 Mar;52(3):446-51.
25 Frøkjær JB, Søfteland E, Graversen C, Dimcevski G, Egsgaard LL, Arendt-Nielsen L, Drewes AM. Central processing of gut pain in diabetespatients with gastrointestinal symptoms. Diabetes Care. 2009 Jul;32(7):1274-7.
2010
26 Brock C, Andresen T, Frøkjær JB, Gale J, Olesen AE, Arendt-Nielsen L, Drewes AM. Central pain mechanisms following combined acid and capsaisin perfusion of the human oesophagus. Eur J Pain. 2010 Mar;14(3):273-81.
27 Frøkjær JB, Søfteland E, Graversen C, Dimcevski G, Drewes AM. Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy. Eur J Clin Invest. 2010 Oct;40(10):883-6
28 Olesen SS, Frokjaer JB, Lelic D, Valeriani M, Drewes AM: Pain-Associated Adaptive Cortical Reorganisation in Chronic Pancreatitis. Pancreatology. 2010;10(6):742-51. Epub 2011 Jan 26.
2011
29 Frøkjær JB, Egsgaard LL, Graversen C, Søfteland E, Dimcevski G, Blauenfeldt RA, Drewes AM. Gastrointestinal symptoms in type-1 diabetes: Is it all about brain plasticity? Eur J Pain. 2011 Mar;15(3):249-57
30 Detlefsen S, Löhr JM, Drewes AM, Frøkjær JB, Klöppel G. Current concepts in the diagnosis and treatment of type 1 and type 2 autoimmune pancreatitis. Recent Pat Inflamm Allergy Drug Discov. 2011 May 1;5(2):136-49.
31 Frøkjær JB, Olesen SS, Graversen C, Andresen T, Lelic D, Drewes AM: Neuroimaging of the human visceral pain system – A methodological review. Scand. J. Pain. 2011 Jul;2:95-104.
32 Olesen SS, Graversen C, Olesen AE, Frøkjær JB, Wilder-Smith OHG, van Goor H, Valeriani M, Drewes AM. Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis.Pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. Aliment Pharmacol Ther. 2011 Oct;34(8):878-887.
33 Gregersen H, Drewes AM, Frøkjaer JB, Krarup AL, Lottrup C, Farmer AD, Aziz Q, Hobson AR. Mechanism-based evaluation and treatment of esophageal disorders. Ann N Y Acad Sci. 2011 Sep;1232(1):341-8.
34 McMahon BP, Rao SS, Gregersen H, Kwiatek MA, Pandolfino JE, Drewes AM, Krarup AL, Lottrup C, Frøkjaer JB. Distensibility testing of the esophagus. Ann N Y Acad Sci. 2011 Sep;1232(1):331-340.
35 Frøkjær JB, Olesen SS, Gram M, Yavarian Y, Bouwense SAW, Wilder-Smith OHG, Drewes AM. Altered Brain Microstructure assessed by Diffusion Tensor Imaging in Patients with Chronic Pancreatitis. Gut. 2011 Nov;60(11):1554-62. Editorial in Gut. 2011 Nov;60(11):1445-6.
36 Søfteland E, Dimcevski G, Graversen C, Nedrebø BG, Drewes AM, Frøkjær JB. Effects of isolated hyperinsulinaemia on sensory function in healthy adults. Exp Clin Endocrinol Diabetes. 2011 Nov;119(10):604-9.
37 Frøkjær JB, Bouwense SAW, Olesen SS, Lundager FH, Eskildsen SF, van Goor H, Wilder-Smith OHG, Drewes AM. Changes in Cortical Thickness in Patients with Chronic Pancreatitis: A useful Indicator of a Reorganized Pain System? In press. Clinical Gastroenterology and Hepatology
